University of California to be granted CRISPR patent


(Reuters) – The University of California will soon be granted a potentially valuable patent on the revolutionary gene-editing technology known as CRISPR, according to a document filed by the U.S. patent office on Friday.

The decision by the U.S. Patent and Trademark Office to grant the patent could further fuel a long-running rivalry between the university and the Broad Institute, a biological and genomic research center affiliated with the Massachusetts Institute of Technology (MIT) and Harvard that also holds patents on CRISPR.

The so-called notice of allowance from the Patent and Trademark Office means that the patent will likely be issued within eight weeks. Once issued, the patent could still face challenges in administrative or court proceedings.

The University of California and the Broad Institute did not immediately respond to requests for comment. Both institutions have licensed their CRISPR intellectual property to biotech companies.

Patent rights to CRISPR could eventually be worth billions of dollars, as the technology could revolutionize the treatment of diseases, crop engineering and other areas.

CRISPR, first discovered as a kind of immune system occurring naturally in bacteria, works as a molecular scissors that can trim away unwanted pieces of genetic material, such as a gene mutation associated with diseases, and replace them with new ones. Easier to use than older techniques, it has quickly become a preferred method of gene editing in research labs.

The patent being approved stems from an application filed by microbiologists Jennifer Doudna of the University of California at Berkeley and Emmanuelle Charpentier of the University of Vienna in 2012. The scientists filed the application, the first ever for a CRISPR-related patent, after they discovered how CRISPR could be used to edit genomes in simple pieces of DNA called plasmids.

A team at the Broad Institute led by bioengineer Feng Zhang applied for their own patent six months later, but paid for a fast-track review process, which landed them the first CRISPR patent in 2014. The Broad’s patents covered CRISPR’s use in eukaryotic cells, which are more advanced than bacteria, including plant, animal and human cells.

In April 2015, the University of California filed a petition with the Patent and Trademark Office challenging the Broad Institute’s patents, claiming they covered the same thing as the university’s earlier application.

However, the board rejected that petition, allowing both the University of California’s application and the Broad Institute patents to stand. Its decision was upheld by a federal appeals court last year.

Reporting by Brendan Pierson in New York; editing by Bill Berkrot and Rosalba O’Brien



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